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Depakote Delayed-Release Tablets



Generic Name: Divalproex (dye-VAL-proe-ex)



Brand Name: Depakote



Depakote Delayed-Release Tablets are used for:

Controlling certain types of seizures in the treatment of epilepsy. It is also used to treat the manic phase of bipolar disorders (manic-depressive illness), and to prevent migraine headaches. Depakote Delayed-Release Tablets are an anticonvulsant. It works by reducing or preventing the number of seizures by controlling the abnormal activity of nerve impulses in the brain and central nervous system. Exactly how it works to treat bipolar disorder and migraine headache is not known.

Before using Depakote Delayed-Release Tablets:

Some medical conditions may interact with Depakote Delayed-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, planning to become pregnant, are breast-feeding, or are of childbearing age if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a history of alcohol abuse, liver problems, metabolic disease, blood disease, HIV infection, cytomegalovirus (CMV) infection, high blood levels of ammonia or glutamine, low body temperature, low levels of albumin, brain problems (eg, organic brain disease), mental retardation, inflammation of the pancreas, kidney problems, or low levels of white blood cells, or if you are scheduled for surgery if you have a history of ornithine transcarbamylase deficiency or unexplained coma if you have a family history of urea cycle disorders or unexplained infant deaths if you have a history of mental or mood problems (eg, depression), or suicidal thoughts or actions if you take any other medicine for seizures Some MEDICINES MAY INTERACT with Depakote Delayed-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following: Benzodiazepines (eg, diazepam), carbamazepine, erythromycin, felbamate, fluoxetine, guanfacine, isoniazid, ketoconazole, risperidone, or salicylates (eg, aspirin) because the risk of serious side effects of Depakote Delayed-Release Tablets, including changes in vision or other vision problems, clumsiness or unsteadiness, drowsiness, nausea, or vomiting, may be increased Clonazepam because the risk of seizures may be increased Topiramate because the risk of high ammonium levels, brain problems, or an unusual drop in body temperature may be increased Acyclovir, cancer medicines, carbapenem antibiotics (eg, ertapenem, imipenem, meropenem), cholestyramine, hydantoins (eg, phenytoin), mefloquine, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), oral contraceptives (eg, birth control pills), or rifampin because they may decrease Depakote Delayed-Release Tablets's effectiveness Anticoagulants (eg, warfarin), barbiturates (eg, phenobarbital), ethosuximide, lamotrigine, methylphenidate, primidone, tolbutamide, tricyclic antidepressants (eg, amitriptyline), or zidovudine because the risk of their side effects may be increased by Depakote Delayed-Release Tablets This may not be a complete list of all interactions that may occur. Ask your health care provider if Depakote Delayed-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Depakote Delayed-Release Tablets:

Use Depakote Delayed-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions. An extra patient leaflet is available with Depakote Delayed-Release Tablets. Talk to your pharmacist if you have questions about this information. Take Depakote Delayed-Release Tablets by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. Swallow Depakote Delayed-Release Tablets whole. Do not break, crush, or chew before swallowing. Do not stop taking Depakote Delayed-Release Tablets suddenly, especially if you are taking Depakote Delayed-Release Tablets to prevent seizures. Suddenly stopping Depakote Delayed-Release Tablets may cause severe seizures to occur. If you need to stop Depakote Delayed-Release Tablets, your doctor will gradually lower your dose. Taking Depakote Delayed-Release Tablets at the same time each day will help you remember to take it. Continue to take Depakote Delayed-Release Tablets even if you feel well. Do not miss any doses. Depakote Delayed-Release Tablets works best when there is a constant level of it in your body. If you miss a dose of Depakote Delayed-Release Tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Ask your health care provider any questions you may have about how to use Depakote Delayed-Release Tablets.

Possible side effects of Depakote Delayed-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome: Change in appetite; constipation; diarrhea; dizziness; drowsiness; hair loss; headache; indigestion; nausea; stomach cramps or pain; trouble sleeping; vomiting; weakness; weight changes. Seek medical attention right away if any of these SEVERE side effects occur: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal thinking; change in menstrual period; changes in behavior; chest pain; confusion; dark, tarry, or bloody stools; dark urine; difficulty speaking; difficulty urinating or other urination problems; extreme tiredness; fast or irregular heartbeat; hallucinations; hearing loss; involuntary movements of the arms and legs; involuntary movements or chewing movements of the face, jaw, mouth, or tongue; joint pain; lack of energy; loss of appetite; loss of coordination; loss of seizure control; memory loss; new or worsening mental or mood changes (eg, aggressiveness, agitation, anxiety, depression, exaggerated feeling of well-being, hostility, impulsiveness, inability to sit still, irritability, panic attacks, restlessness); nosebleed; pounding in the chest; red, swollen, blistered, or peeling skin; severe or persistent nausea, vomiting, or stomach pain; shortness of breath; suicidal thoughts or actions; swelling of the arms or legs; symptoms of infection (eg, fever, chills, sore throat); tremor; unusual bleeding or bruising; unusual weakness; vision changes or blurred vision; yellowing of the skin or eyes. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at _ttp://www.fda.gov/medwatch.